Metabolic fate of 1, 3-butanediol in the rat: conversion to β-hydroxybutyrate
RL Tate, MA Mehlman, RB Tobin - The Journal of Nutrition, 1971 - Elsevier
High speed supernatants of extracts of rat liver exhibited an NAD+-dependent oxidation of
both 1, 3-butanediol (BD) and ethanol at pH 10 similar to that shown by crystalline horse
liver alcohol dehydrogenase. Inhibition of rat liver alcohol dehydrogenase in vivo by
intraperitoneal injection of pyrazole or n-butyraldoxime prior to sacrifice for liver slice
experiments brought about inhibition of ketone body production from BD. Ethanol and BD
oxidation by rat liver extracts in vitro was also strongly inhibited by pyrazole. The ethanol …
both 1, 3-butanediol (BD) and ethanol at pH 10 similar to that shown by crystalline horse
liver alcohol dehydrogenase. Inhibition of rat liver alcohol dehydrogenase in vivo by
intraperitoneal injection of pyrazole or n-butyraldoxime prior to sacrifice for liver slice
experiments brought about inhibition of ketone body production from BD. Ethanol and BD
oxidation by rat liver extracts in vitro was also strongly inhibited by pyrazole. The ethanol …
