Preeclampsia is a unique pregnancy disorder whose patho-physiology is initiated early in
gestation, while clinical manifestations typically occur in mid-to-late pregnancy. Thus,
prevention should optimally be initiated in early gestation. The intimate interaction between
PIF, secreted early by viable embryos, and its host-mother provides insight into putative
mechanisms of preeclampsia prevention. PIF is instrumental at the two critical events
underlying preeclampsia. At first, shallow implantation leads to impaired placentation …