Involvement of OSP/claudin‐11 in oligodendrocyte membrane interactions: Role in biology and disease
JM Bronstein, S Tiwari‐Woodruff… - Journal of …, 2000 - Wiley Online Library
JM Bronstein, S Tiwari‐Woodruff, AG Buznikov, DB Stevens
Journal of neuroscience research, 2000•Wiley Online LibraryOligodendrocyte‐specific protein (OSP/claudin‐11) is a four transmembrane protein
concentrated in central nervous system myelin. Recent evidence has emerged suggesting
that OSP/claudin‐11 is involved in membrane interactions at tight junctions and with the
extracellular matrix. OSP/claudin‐11 seems to modulate proliferation and migration of
oligodendrocytes presumably through these interactions. Furthermore, evidence is
presented implicating OSP/claudin‐11 as an autoantigen in the development of autoimmune …
concentrated in central nervous system myelin. Recent evidence has emerged suggesting
that OSP/claudin‐11 is involved in membrane interactions at tight junctions and with the
extracellular matrix. OSP/claudin‐11 seems to modulate proliferation and migration of
oligodendrocytes presumably through these interactions. Furthermore, evidence is
presented implicating OSP/claudin‐11 as an autoantigen in the development of autoimmune …
Abstract
Oligodendrocyte‐specific protein (OSP/claudin‐11) is a four transmembrane protein concentrated in central nervous system myelin. Recent evidence has emerged suggesting that OSP/claudin‐11 is involved in membrane interactions at tight junctions and with the extracellular matrix. OSP/claudin‐11 seems to modulate proliferation and migration of oligodendrocytes presumably through these interactions. Furthermore, evidence is presented implicating OSP/claudin‐11 as an autoantigen in the development of autoimmune demyelinating disease. J. Neurosci. Res. 59:706–711, 2000 © 2000 Wiley‐Liss, Inc.
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