The slit diaphragm: a signaling platform to regulate podocyte function
From recent data, a novel concept of a highly dynamic slit protein complex is emerging. Slit
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and
cytoskeletal organization. This concept is further supported by the fact that many clinically
relevant mutations of slit diaphragm proteins interfere with signaling processes at the slit
diaphragm and cause proteinuria and progressive kidney disease.
diaphragm proteins are contributing to the regulation of cell polarity, cell survival and
cytoskeletal organization. This concept is further supported by the fact that many clinically
relevant mutations of slit diaphragm proteins interfere with signaling processes at the slit
diaphragm and cause proteinuria and progressive kidney disease.
Summary
From recent data, a novel concept of a highly dynamic slit protein complex is emerging. Slit diaphragm proteins are contributing to the regulation of cell polarity, cell survival and cytoskeletal organization. This concept is further supported by the fact that many clinically relevant mutations of slit diaphragm proteins interfere with signaling processes at the slit diaphragm and cause proteinuria and progressive kidney disease.
Lippincott Williams & Wilkins