How cells respond to interferons revisited: from early history to current complexity
GR Stark - Cytokine & growth factor reviews, 2007 - Elsevier
A brief account of how I became involved in interferon research is followed by recollections
of key experiments that led to the discovery of the roles of the JAKs and STATs in interferon-
dependent signaling. I then outline the complex responses of cells to interferons, including
the roles of kinases other than JAKs and transcription factors other than STATs, differential
responses to interferons α and β, modulation of response by prior exposure to other
cytokines (“priming”), cytokine-dependent induction of high level expression of STATs 1 and …
of key experiments that led to the discovery of the roles of the JAKs and STATs in interferon-
dependent signaling. I then outline the complex responses of cells to interferons, including
the roles of kinases other than JAKs and transcription factors other than STATs, differential
responses to interferons α and β, modulation of response by prior exposure to other
cytokines (“priming”), cytokine-dependent induction of high level expression of STATs 1 and …
