Complement deposition on renal histopathology of patients with diabetic nephropathy
ZJ Sun, XQ Li, DY Chang, SX Wang, G Liu, M Chen… - Diabetes & …, 2019 - Elsevier
Aims As the potential role of the complement system in diabetic nephropathy (DN) is
increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on
renal histopathology, as well as its association with clinical and pathological parameters, in
DN patients. Methods Renal biopsy specimens from 161 DN patients were investigated
using direct immunofluorescence, light, and electron microscopy. For direct
immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed …
increasingly reported, this study aimed to investigate C1q and C3c deposition as seen on
renal histopathology, as well as its association with clinical and pathological parameters, in
DN patients. Methods Renal biopsy specimens from 161 DN patients were investigated
using direct immunofluorescence, light, and electron microscopy. For direct
immunofluorescence, staining for C1q and C3c on fresh-frozen renal tissue was performed …
