[HTML][HTML] Regulation of hepatic glucose uptake and storage in vivo

MC Moore, KC Coate, JJ Winnick, Z An… - Advances in …, 2012 - Elsevier
In the postprandial state, the liver takes up and stores glucose to minimize the fluctuation of
glycemia. Elevated insulin concentrations, an increase in the load of glucose reaching the
liver, and the oral/enteral/portal vein route of glucose delivery (compared with the peripheral
intravenous route) are factors that increase the rate of net hepatic glucose uptake (NHGU).
The entry of glucose into the portal vein stimulates a portal glucose signal that not only
enhances NHGU but concomitantly reduces muscle glucose uptake to ensure appropriate …