Wnt-dependent β-catenin signaling is activated after unilateral ureteral obstruction, and recombinant secreted frizzled-related protein 4 alters the progression of renal …
K Surendran, S Schiavi, KA Hruska - Journal of the American …, 2005 - journals.lww.com
Abstract β-Catenin functions as a transducer of Wnt signals to the nucleus, where it interacts
with the T cell factor (TCF) family of DNA binding proteins to regulate gene expression. On
the basis of the genes regulated by β-catenin and TCF in various biologic settings, two
predicted functions of β-catenin/TCF-dependent transcription are to mediate the loss of
epithelial polarity and to promote fibroblast activities, such as the increased synthesis of
fibronectin during chronic renal disease. These predictions were tested by determination of …
with the T cell factor (TCF) family of DNA binding proteins to regulate gene expression. On
the basis of the genes regulated by β-catenin and TCF in various biologic settings, two
predicted functions of β-catenin/TCF-dependent transcription are to mediate the loss of
epithelial polarity and to promote fibroblast activities, such as the increased synthesis of
fibronectin during chronic renal disease. These predictions were tested by determination of …