Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction
A Glinka, W Wu, H Delius, AP Monaghan… - Nature, 1998 - nature.com
A Glinka, W Wu, H Delius, AP Monaghan, C Blumenstock, C Niehrs
Nature, 1998•nature.comThe Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity,
the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which
encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a
new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and
necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling,
suggesting that dkk genes encode a family of secreted Wnt inhibitors.
the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which
encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a
new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and
necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling,
suggesting that dkk genes encode a family of secreted Wnt inhibitors.
Abstract
The Spemann organizer in amphibian embryos is a tissue with potent head-inducing activity, the molecular nature of which is unresolved. Here we describe dickkopf-1 (dkk-1), which encodes Dkk-1, a secreted inducer of Spemann's organizer in Xenopus and a member of a new protein family. Injections of mRNA and antibody indicate that dkk-1 is sufficient and necessary to cause head induction. dkk-1 is a potent antagonist of Wnt signalling, suggesting that dkk genes encode a family of secreted Wnt inhibitors.
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