Cocaine has been shown to activate the sympathoadrenal system in both animal and
human studies. Controlled human studies have found inconclusive results regarding
whether acute cocaine treatment elevates plasma epinephrine and norepinephrine
concentrations. The purpose of this study was to investigate whether commonly abused
doses of cocaine increase plasma epinephrine and norepinephrine concentrations in
humans, in a double-blind, placebo-controlled study. Five male cocaine users were given an …