Endothelial glycocalyx biomarkers increase in patients with infection during Emergency Department treatment
L Smart, SPJ Macdonald, S Burrows, E Bosio… - Journal of critical …, 2017 - Elsevier
Purpose Endothelial glycocalyx (EG) shedding may promote organ failure in sepsis. This
study describes temporal changes in EG biomarkers from Emergency Department (ED)
arrival, and associations with clinical characteristics. Materials and Methods This
prospective observational study included 23 patients with simple infection, 86 with sepsis
and 29 healthy controls. Serum EG biomarkers included syndecan-1, syndecan-4 and
hyaluronan. Samples were taken on enrolment in the ED (T0), 1 hour (T1), 3 hours (T3) and …
study describes temporal changes in EG biomarkers from Emergency Department (ED)
arrival, and associations with clinical characteristics. Materials and Methods This
prospective observational study included 23 patients with simple infection, 86 with sepsis
and 29 healthy controls. Serum EG biomarkers included syndecan-1, syndecan-4 and
hyaluronan. Samples were taken on enrolment in the ED (T0), 1 hour (T1), 3 hours (T3) and …
