Caveolae are specialized lipid rafts localized on the cytoplasmic surface of the sarcolemmal
membrane. Caveolae contribute to the maintenance of plasma membrane integrity,
constitute specific macromolecular complexes that provide highly localized regulation of ion
channels, and regulate vesicular trafficking and signal transduction. In skeletal muscle, the
main structural assembly of caveolae is mediated by caveolin-3. Another family of adapter
proteins, the cavins, is involved in the regulation of caveolae function and in the trafficking of …