[HTML][HTML] Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis
Interleukin 1 Genetics Consortium - The Lancet Diabetes & …, 2015 - Elsevier
Background To investigate potential cardiovascular and other effects of long-term
pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce
inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score
combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are
located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an
endogenous inhibitor of both IL-1α and IL-1β); both alleles increase soluble IL-1Ra protein …
pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce
inhibition of IL-1, a master regulator of inflammation. Methods We created a genetic score
combining the effects of alleles of two common variants (rs6743376 and rs1542176) that are
located upstream of IL1RN, the gene encoding the IL-1 receptor antagonist (IL-1Ra; an
endogenous inhibitor of both IL-1α and IL-1β); both alleles increase soluble IL-1Ra protein …
