Evidence that low-grade systemic inflammation can induce islet dysfunction as measured by impaired calcium handling
SB Dula, M Jecmenica, R Wu, P Jahanshahi… - Cell calcium, 2010 - Elsevier
In obesity and the early stages of type 2 diabetes (T2D), proinflammatory cytokines are
mildly elevated in the systemic circulation. This low-grade systemic inflammation exposes
pancreatic islets to these circulating cytokines at much lower levels than seen within the islet
during insulitis. These low-dose effects have not been well described. We examined mouse
islets treated overnight with a low-dose cytokine combination commonly associated with
inflammation (TNF-alpha, IL-1 beta, and IFN-gamma). We then examined islet function …
mildly elevated in the systemic circulation. This low-grade systemic inflammation exposes
pancreatic islets to these circulating cytokines at much lower levels than seen within the islet
during insulitis. These low-dose effects have not been well described. We examined mouse
islets treated overnight with a low-dose cytokine combination commonly associated with
inflammation (TNF-alpha, IL-1 beta, and IFN-gamma). We then examined islet function …