Short-term exposure of rat pancreatic islets to human interleukin-1β increases cellular uptake of calcium
LAH Borg, DL Eizirik - Immunology letters, 1990 - Elsevier
Abstract Interleukin-1 (IL-1) may be one of the effector molecules involved in the destruction
of the pancreatic islet B cells resulting in insulin-dependent diabetes mellitus. Isolated islets
exposed to IL-1 show an acutely increased substrate metabolism and insulin release, which
is followed by a metabolic and functional suppression. Since an increased cellular uptake of
calcium in the islets may be associated with both nutrient-induced insulin release and cell
damage, the effects of recombinant IL-1β (rIL-β) on net cellular calcium uptake by isolated …
of the pancreatic islet B cells resulting in insulin-dependent diabetes mellitus. Isolated islets
exposed to IL-1 show an acutely increased substrate metabolism and insulin release, which
is followed by a metabolic and functional suppression. Since an increased cellular uptake of
calcium in the islets may be associated with both nutrient-induced insulin release and cell
damage, the effects of recombinant IL-1β (rIL-β) on net cellular calcium uptake by isolated …