[HTML][HTML] Insulin-like growth factor-1 increases synthesis of collagen type I via induction of the mRNA-binding protein LARP6 expression and binding to the 5′ stem …
CD Blackstock, Y Higashi, S Sukhanov, SY Shai… - Journal of Biological …, 2014 - ASBMB
Collagen content in atherosclerotic plaque is a hallmark of plaque stability. Our earlier
studies showed that insulin-like growth factor-1 (IGF-1) increases collagen content in
atherosclerotic plaques of Apoe−/− mice. To identify mechanisms we investigated the effect
of IGF-1 on the la ribonucleoprotein domain family member 6 (LARP6). LARP6 binds a stem-
loop motif in the 5′-UTR of the mRNAs encoding the collagen type I α-subunits (α1 (I) and
α2 (I)), and coordinates their translation into the heterotrimeric collagen type I molecule. In …
studies showed that insulin-like growth factor-1 (IGF-1) increases collagen content in
atherosclerotic plaques of Apoe−/− mice. To identify mechanisms we investigated the effect
of IGF-1 on the la ribonucleoprotein domain family member 6 (LARP6). LARP6 binds a stem-
loop motif in the 5′-UTR of the mRNAs encoding the collagen type I α-subunits (α1 (I) and
α2 (I)), and coordinates their translation into the heterotrimeric collagen type I molecule. In …