Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients
G Jia, RW Erickson, DF Choy, S Mosesova… - Journal of Allergy and …, 2012 - Elsevier
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients.
We recently described a distinct subtype of asthma defined by the expression of genes
inducible by TH2 cytokines in bronchial epithelium. This gene signature, which includes
periostin, is present in approximately half of asthmatic patients and correlates with
eosinophilic airway inflammation. However, identification of this subtype depends on
invasive airway sampling, and hence noninvasive biomarkers of this phenotype are …
We recently described a distinct subtype of asthma defined by the expression of genes
inducible by TH2 cytokines in bronchial epithelium. This gene signature, which includes
periostin, is present in approximately half of asthmatic patients and correlates with
eosinophilic airway inflammation. However, identification of this subtype depends on
invasive airway sampling, and hence noninvasive biomarkers of this phenotype are …