Commentary: IL-4 and IL-13 receptors and signaling
SM McCormick, NM Heller - Cytokine, 2015 - Elsevier
SM McCormick, NM Heller
Cytokine, 2015•ElsevierAbstract Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13
and their receptors in normal gestation, fetal development and neurological function and in
the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their
receptors has revealed important clues about cytokine biology and led to the development of
numerous experimental therapeutics. Here we aim to highlight new discoveries and …
immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13
and their receptors in normal gestation, fetal development and neurological function and in
the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their
receptors has revealed important clues about cytokine biology and led to the development of
numerous experimental therapeutics. Here we aim to highlight new discoveries and …
Abstract
Interleukin (IL)-4 and IL-13 were discovered approximately 30 years ago and were immediately linked to allergy and atopic diseases. Since then, new roles for IL-4 and IL-13 and their receptors in normal gestation, fetal development and neurological function and in the pathogenesis of cancer and fibrosis have been appreciated. Studying IL-4/-13 and their receptors has revealed important clues about cytokine biology and led to the development of numerous experimental therapeutics. Here we aim to highlight new discoveries and consolidate concepts in the field of IL-4 and IL-13 structure, receptor regulation, signaling and experimental therapeutics.
Elsevier