Cocaine toxicity and isoflurane anesthesia: hemodynamic, myocardial metabolic, and regional blood flow effects in swine

JF Boylan, DCH Cheng, AN Sandler… - Journal of cardiothoracic …, 1996 - Elsevier
OBJECTIVES:: Increasing numbers of people use cocaine recreationally and may require
anesthesia care, having recently abused the drug. However, no data currently exist
concerning potential interactions between toxic levels of cocaine and volatile anesthetic
agents. This study investigated the effects of cocaine infusion on systemic hemodynamics,
myocardial metabolism, and regional organ blood flow in relation to depth of isoflurane
anesthesia. DESIGN:: Prospective, randomized, controlled trial. SETTING:: A laboratory at a …