Importance Estimates from claims-based analyses suggest that the incidence of sepsis is
increasing and mortality rates from sepsis are decreasing. However, estimates from claims
data may lack clinical fidelity and can be affected by changing diagnosis and coding
practices over time. Objective To estimate the US national incidence of sepsis and trends
using detailed clinical data from the electronic health record (EHR) systems of diverse
hospitals. Design, Setting, and Population Retrospective cohort study of adult patients …