[HTML][HTML] Critical role of the neonatal Fc receptor (FcRn) in the pathogenic action of antimitochondrial autoantibodies synergizing with anti-desmoglein autoantibodies …
Y Chen, A Chernyavsky, RJ Webber, SA Grando… - Journal of Biological …, 2015 - ASBMB
Pemphigus vulgaris (PV) is a life-long, potentially fatal IgG autoantibody-mediated blistering
disease targeting mucocutaneous keratinocytes (KCs). PV patients develop pathogenic anti-
desmoglein (Dsg) 3±1 and antimitochondrial antibodies (AMA), but it remained unknown
whether and how AMA enter KCs and why other cell types are not affected in PV. Therefore,
we sought to elucidate mechanisms of cell entry, trafficking, and pathogenic action of AMA in
PV. We found that PVIgGs associated with neonatal Fc receptor (FcRn) on the cell …
disease targeting mucocutaneous keratinocytes (KCs). PV patients develop pathogenic anti-
desmoglein (Dsg) 3±1 and antimitochondrial antibodies (AMA), but it remained unknown
whether and how AMA enter KCs and why other cell types are not affected in PV. Therefore,
we sought to elucidate mechanisms of cell entry, trafficking, and pathogenic action of AMA in
PV. We found that PVIgGs associated with neonatal Fc receptor (FcRn) on the cell …