The transcription factor Pax6 is required for pancreatic β cell identity, glucose-regulated ATP synthesis, and Ca2+ dynamics in adult mice
RK Mitchell, MS Nguyen-Tu, P Chabosseau… - Journal of Biological …, 2017 - ASBMB
Heterozygous mutations in the human paired box gene PAX6 lead to impaired glucose
tolerance. Although embryonic deletion of the Pax6 gene in mice leads to loss of most
pancreatic islet cell types, the functional consequences of Pax6 loss in adults are poorly
defined. Here we developed a mouse line in which Pax6 was selectively inactivated in β
cells by crossing animals with floxed Pax6 alleles to mice expressing the inducible
Pdx1CreERT transgene. Pax6 deficiency, achieved by tamoxifen injection, caused …
tolerance. Although embryonic deletion of the Pax6 gene in mice leads to loss of most
pancreatic islet cell types, the functional consequences of Pax6 loss in adults are poorly
defined. Here we developed a mouse line in which Pax6 was selectively inactivated in β
cells by crossing animals with floxed Pax6 alleles to mice expressing the inducible
Pdx1CreERT transgene. Pax6 deficiency, achieved by tamoxifen injection, caused …
