Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator–inducible T-cell costimulator …
Background Atopic diseases, including asthma, exacerbate type 2 immune responses and
involve a number of immune cell types, including regulatory T (Treg) cells and the emerging
type 2 innate lymphoid cells (ILC2s). Although ILC2s are potent producers of type 2
cytokines, the regulation of ILC2 activation and function is not well understood. Objective In
the present study, for the first time, we evaluate how Treg cells interact with pulmonary ILC2s
and control their function. Methods ILC2s and Treg cells were evaluated by using in vitro …
involve a number of immune cell types, including regulatory T (Treg) cells and the emerging
type 2 innate lymphoid cells (ILC2s). Although ILC2s are potent producers of type 2
cytokines, the regulation of ILC2 activation and function is not well understood. Objective In
the present study, for the first time, we evaluate how Treg cells interact with pulmonary ILC2s
and control their function. Methods ILC2s and Treg cells were evaluated by using in vitro …