IL-10, TGF-β, and glucocorticoid prevent the production of type 2 cytokines in human group 2 innate lymphoid cells
N Ogasawara, JA Poposki, AI Klingler… - Journal of Allergy and …, 2018 - jacionline.org
FIG 1. Presence of receptors for IL-10 and TGF-b on human ILC2. Representative
histograms of flow cytometric plots for IL-10RA (A) and TGFBR2 (B) in ILC2s from a blood
sample and an NP are shown. Levels of cell surface expression of receptors on ILC2s from
blood (n 5 10) and NPs (n 5 10) are shown by geometric mean fluorescence intensity (gMFI).
PBMCs were stimulated with medium control (filled), 1 ng/mL IL-10 (dashed line), or 10
(solid) ng/mL IL-10 for 15 minutes. The level of intracellular phospho-STAT3 in blood ILC2s …
histograms of flow cytometric plots for IL-10RA (A) and TGFBR2 (B) in ILC2s from a blood
sample and an NP are shown. Levels of cell surface expression of receptors on ILC2s from
blood (n 5 10) and NPs (n 5 10) are shown by geometric mean fluorescence intensity (gMFI).
PBMCs were stimulated with medium control (filled), 1 ng/mL IL-10 (dashed line), or 10
(solid) ng/mL IL-10 for 15 minutes. The level of intracellular phospho-STAT3 in blood ILC2s …