[HTML][HTML] MyD88-dependent dendritic and epithelial cell crosstalk orchestrates immune responses to allergens
Sensitization to inhaled allergens is dependent on activation of conventional dendritic cells
(cDCs) and on the adaptor molecule, MyD88. However, many cell types in the lung express
Myd88, and it is unclear how signaling in these different cell types reprograms cDCs and
leads to allergic inflammation of the airway. By combining ATAC-seq with RNA profiling, we
found that MyD88 signaling in cDCs maintained open chromatin at select loci even at steady
state, allowing genes to be rapidly induced during allergic sensitization. A distinct set of …
(cDCs) and on the adaptor molecule, MyD88. However, many cell types in the lung express
Myd88, and it is unclear how signaling in these different cell types reprograms cDCs and
leads to allergic inflammation of the airway. By combining ATAC-seq with RNA profiling, we
found that MyD88 signaling in cDCs maintained open chromatin at select loci even at steady
state, allowing genes to be rapidly induced during allergic sensitization. A distinct set of …