RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation
Background Mitochondrial metabolism is known to be important for T-cell activation.
However, its involvement in effector T-cell differentiation has just begun to gain attention.
Importantly, how metabolic pathways are integrated with T-cell activation and effector cell
differentiation and function remains largely unknown. Objective We sought to test our
hypothesis that RhoA GTPase orchestrates glycolysis for TH 2 cell differentiation and TH 2-
mediated allergic airway inflammation. Methods Conditional RhoA-deficient mice were …
However, its involvement in effector T-cell differentiation has just begun to gain attention.
Importantly, how metabolic pathways are integrated with T-cell activation and effector cell
differentiation and function remains largely unknown. Objective We sought to test our
hypothesis that RhoA GTPase orchestrates glycolysis for TH 2 cell differentiation and TH 2-
mediated allergic airway inflammation. Methods Conditional RhoA-deficient mice were …