[HTML][HTML] Bone morphogenetic protein 4 promotes vascular smooth muscle contractility by activating microRNA-21 (miR-21), which down-regulates expression of family …
H Kang, BN Davis-Dusenbery, PH Nguyen… - Journal of Biological …, 2012 - ASBMB
The bone morphogenetic protein 4 (BMP4) signaling pathway plays a critical role in the
promotion and maintenance of the contractile phenotype in vascular smooth muscle cell
(vSMC). Misexpression or inactivating mutations of the BMP receptor gene can lead to
dedifferentiation of vSMC characterized by increased migration and proliferation that is
linked to vascular proliferative disorders. Previously we demonstrated that vSMCs increase
microRNA-21 (miR-21) biogenesis upon BMP4 treatment, which induces contractile gene …
promotion and maintenance of the contractile phenotype in vascular smooth muscle cell
(vSMC). Misexpression or inactivating mutations of the BMP receptor gene can lead to
dedifferentiation of vSMC characterized by increased migration and proliferation that is
linked to vascular proliferative disorders. Previously we demonstrated that vSMCs increase
microRNA-21 (miR-21) biogenesis upon BMP4 treatment, which induces contractile gene …