[HTML][HTML] The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis
H Higuchi, SF Bronk, Y Takikawa, N Werneburg… - Journal of biological …, 2001 - ASBMB
Toxic bile salts induce hepatocyte apoptosis by both Fas-dependent and-independent
mechanisms. In this study, we examined the cellular mechanisms responsible for Fas-
independent, bile acid-mediated apoptosis. HuH-7 cells, which are known to be Fas
deficient, were stably transfected with the sodium-dependent bile acid transporting
polypeptide. The toxic bile acid glycochenodeoxycholate (GCDC)-induced apoptosis in
these cells in a time-and concentration-dependent manner. Apoptosis and mitochondrial …
mechanisms. In this study, we examined the cellular mechanisms responsible for Fas-
independent, bile acid-mediated apoptosis. HuH-7 cells, which are known to be Fas
deficient, were stably transfected with the sodium-dependent bile acid transporting
polypeptide. The toxic bile acid glycochenodeoxycholate (GCDC)-induced apoptosis in
these cells in a time-and concentration-dependent manner. Apoptosis and mitochondrial …