Anti-inflammatory activity profile of JANEX-1 in preclinical animal models
FM Uckun, H Tibbles, Z Ozer, S Qazi… - Bioorganic & medicinal …, 2008 - Elsevier
FM Uckun, H Tibbles, Z Ozer, S Qazi, A Vassilev
Bioorganic & medicinal chemistry, 2008•ElsevierWe examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in
several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-
inflammatory activity in each of these preclinical models, including mouse models of
peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore,
JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study
may provide the basis for new and effective treatment as well as prevention programs for …
several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-
inflammatory activity in each of these preclinical models, including mouse models of
peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore,
JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study
may provide the basis for new and effective treatment as well as prevention programs for …
We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndrome. Therefore, JANEX-1 may prove useful as a broad-spectrum anti-inflammatory agent. The present study may provide the basis for new and effective treatment as well as prevention programs for inflammatory disorders.
Elsevier
