[HTML][HTML] Activation of the NLRP3 inflammasome by cellular labile iron
K Nakamura, T Kawakami, N Yamamoto… - Experimental …, 2016 - Elsevier
Highlights•Cellular labile iron stimulates the production of IL-1β from human
monocytes.•Both NLRP3 and caspase-1 are required for the IL-1β production.•Reactive
oxygen species generated by cellular labile iron are involved in the NLRP3 inflammasome
activation through mitochondrial dysfunction and lysosomal damageCellular labile iron,
which contains chelatable redox-active Fe 2+, has been implicated in iron-mediated cellular
toxicity leading to multiple organ dysfunction. Iron homeostasis is controlled by monocytes …
monocytes.•Both NLRP3 and caspase-1 are required for the IL-1β production.•Reactive
oxygen species generated by cellular labile iron are involved in the NLRP3 inflammasome
activation through mitochondrial dysfunction and lysosomal damageCellular labile iron,
which contains chelatable redox-active Fe 2+, has been implicated in iron-mediated cellular
toxicity leading to multiple organ dysfunction. Iron homeostasis is controlled by monocytes …
