The right ventricle under pressure: cellular and molecular mechanisms of right-heart failure in pulmonary hypertension

HJ Bogaard, K Abe, AV Noordegraaf, NF Voelkel - Chest, 2009 - Elsevier
Pulmonary arterial hypertension (PAH) is a deadly disease in which vasoconstriction and
vascular remodeling both lead to a progressive increase in pulmonary vascular resistance.
The response of the right ventricle (RV) to the increased afterload is an important
determinant of patient outcome. Little is known about the cellular and molecular
mechanisms that underlie the transition from compensated hypertrophy to dilatation and
failure that occurs during the course of the disease. Moreover, little is known about the direct …