The role of thrombotic arteriopathy in the pathophysiology of idiopathic pulmonary arterial
hypertension (IPAH) and the use of anticoagulants in the treatment of IPAH are currently
controversial issues. This article reviews the evidence for a role of vascular thrombosis in the
pathophysiology of IPAH. There is sufficient biological rationale to support the notion that
thrombotic arteriopathy is an important pathophysiologic feature of pulmonary arterial
hypertension (PAH) and that its progression materially contributes to disease progression …