G-protein-coupled receptors are appreciated as central components of neurohormonal
signaling. Recently, it turned out that they may also play a role in mechanotransduction. The
angiotensin II AT1 receptor was the first G-protein-coupled receptor claimed to be a
mechanosensor. In the meantime, several other Gq/11-coupled receptors were found to be
sensitive to mechanical stimuli. Furthermore, there is first evidence to support the concept
that Gi/o-coupled receptors are susceptible to mechanical stimulation as well. Mechanical …