[HTML][HTML] Contribution of interferon-β to the murine macrophage response to the Toll-like receptor 4 agonist, lipopolysaccharide
KE Thomas, CL Galligan, RD Newman, EN Fish… - Journal of biological …, 2006 - ASBMB
Interferon-β (IFN-β) has been identified as the signature cytokine induced via the Toll-like
receptor (TLR) 4," MyD88-independent" signaling pathway in macrophages stimulated by
Gram-negative bacterial lipopolysaccharide (LPS). In this study, we analyzed the responses
of macrophages derived from wild-type (IFN-β+/+) mice or mice with a targeted mutation in
IFN-β (IFN-β-/-) to the prototype TLR4 agonist, Escherichia coli LPS. A comparison of basal
and LPS-induced gene expression (by reverse transcription-PCR, real-time PCR, and …
receptor (TLR) 4," MyD88-independent" signaling pathway in macrophages stimulated by
Gram-negative bacterial lipopolysaccharide (LPS). In this study, we analyzed the responses
of macrophages derived from wild-type (IFN-β+/+) mice or mice with a targeted mutation in
IFN-β (IFN-β-/-) to the prototype TLR4 agonist, Escherichia coli LPS. A comparison of basal
and LPS-induced gene expression (by reverse transcription-PCR, real-time PCR, and …