[HTML][HTML] Essential role of IL-6 in protection against H1N1 influenza virus by promoting neutrophil survival in the lung
O Dienz, JG Rud, SM Eaton, PA Lanthier, E Burg… - Mucosal …, 2012 - Elsevier
Influenza virus infection is considered a major worldwide public health problem. Seasonal
infections with the most common influenza virus strains (eg, H1N1) can usually be resolved,
but they still cause a high rate of mortality. The factors that influence the outcome of the
infection remain unclear. Here, we show that deficiency of interleukin (IL)-6 or IL-6 receptor
is sufficient for normally sublethal doses of H1N1 influenza A virus to cause death in mice. IL-
6 is necessary for resolution of influenza infection by protecting neutrophils from virus …
infections with the most common influenza virus strains (eg, H1N1) can usually be resolved,
but they still cause a high rate of mortality. The factors that influence the outcome of the
infection remain unclear. Here, we show that deficiency of interleukin (IL)-6 or IL-6 receptor
is sufficient for normally sublethal doses of H1N1 influenza A virus to cause death in mice. IL-
6 is necessary for resolution of influenza infection by protecting neutrophils from virus …