[HTML][HTML] Circulating B cells with memory and antibody-secreting phenotypes are detectable in pediatric kidney transplant recipients before the development of …
C Fischman, M Fribourg, G Fabrizio, M Cioni… - Transplantation …, 2019 - journals.lww.com
Background. Development of anti–human leukocyte antigen donor-specific antibodies
(DSAs) is associated with antibody-mediated rejection (AMR) and reduced allograft survival
in kidney transplant recipients. Whether changes in circulating lymphocytes anticipate DSA
or AMR development is unclear. Methods. We used time-of-flight mass cytometry to analyze
prospectively collected peripheral blood mononuclear cells (PBMC) from pediatric kidney
transplant recipients who developed DSA (DSA-positive recipients [DSA POS], n= 10) …
(DSAs) is associated with antibody-mediated rejection (AMR) and reduced allograft survival
in kidney transplant recipients. Whether changes in circulating lymphocytes anticipate DSA
or AMR development is unclear. Methods. We used time-of-flight mass cytometry to analyze
prospectively collected peripheral blood mononuclear cells (PBMC) from pediatric kidney
transplant recipients who developed DSA (DSA-positive recipients [DSA POS], n= 10) …
