[HTML][HTML] Markers of graft microvascular endothelial injury may identify harmful donor-specific anti-HLA antibodies and predict kidney allograft loss
Graft microvasculature is a major target of donor-specific antibodies (DSA) and endothelial
damage is direct evidence of antibody-mediated rejection (ABMR). Using
immunohistochemistry, we analyzed the expression of three microvascular endothelial
activation markers (fascin, vimentin, and hsp47), suggestive of endothelial-to-mesenchymal
transition (EndMT) in 351 graft biopsies from 248 kidney recipients, with concomitant
screening of circulating antihuman leukocyte antigen (HLA) DSA at the time of the biopsy …
damage is direct evidence of antibody-mediated rejection (ABMR). Using
immunohistochemistry, we analyzed the expression of three microvascular endothelial
activation markers (fascin, vimentin, and hsp47), suggestive of endothelial-to-mesenchymal
transition (EndMT) in 351 graft biopsies from 248 kidney recipients, with concomitant
screening of circulating antihuman leukocyte antigen (HLA) DSA at the time of the biopsy …
