B-cell exhaustion in HIV infection: the role of immune activation
S Moir, AS Fauci - Current Opinion in HIV and AIDS, 2014 - journals.lww.com
S Moir, AS Fauci
Current Opinion in HIV and AIDS, 2014•journals.lww.comThe phenomenon of B-cell exhaustion is now well established in HIV infection and other
diseases characterized by immune activation. Over the coming years, it will be important to
understand how cellular exhaustion affects the capacity of the immune system to respond to
persisting primary pathogens, as well as to other microbial antigens, whether encountered
as secondary infections or following immunization.
diseases characterized by immune activation. Over the coming years, it will be important to
understand how cellular exhaustion affects the capacity of the immune system to respond to
persisting primary pathogens, as well as to other microbial antigens, whether encountered
as secondary infections or following immunization.
Summary
The phenomenon of B-cell exhaustion is now well established in HIV infection and other diseases characterized by immune activation. Over the coming years, it will be important to understand how cellular exhaustion affects the capacity of the immune system to respond to persisting primary pathogens, as well as to other microbial antigens, whether encountered as secondary infections or following immunization.
Lippincott Williams & Wilkins