[HTML][HTML] LKB1 represses focal adhesion kinase (FAK) signaling via a FAK-LKB1 complex to regulate FAK site maturation and directional persistence
ER Kline, J Shupe, M Gilbert-Ross, W Zhou… - Journal of Biological …, 2013 - ASBMB
Liver kinase β1 (LKB1, also known as STK11) is a serine/threonine kinase that has multiple
cellular functions including the regulation of cell polarity and motility. Murine proteomic
studies show that LKB1 loss causes aberrant adhesion signaling; however, the mechanistic
underpinnings of this relationship are unknown. We show that cells stably depleted of LKB1
or its co-activator STRADα have increased phosphorylation of focal adhesion kinase (FAK)
at Tyr 397/Tyr 861 and enhanced adhesion to fibronectin. LKB1 associates in a complex …
cellular functions including the regulation of cell polarity and motility. Murine proteomic
studies show that LKB1 loss causes aberrant adhesion signaling; however, the mechanistic
underpinnings of this relationship are unknown. We show that cells stably depleted of LKB1
or its co-activator STRADα have increased phosphorylation of focal adhesion kinase (FAK)
at Tyr 397/Tyr 861 and enhanced adhesion to fibronectin. LKB1 associates in a complex …