IL-13 and idiopathic pulmonary fibrosis: Possible links and new therapeutic strategies
G Passalacqua, M Mincarini, D Colombo… - Pulmonary …, 2017 - Elsevier
The recent advances in the knowledge of immunological aspects of many pulmonary
diseases, allowed to identify cells, biological functions, cytokines, and receptors that are
preferentially involved in each disease. This is the case of asthma, where IL-13 (together
with IL-4) is recognized as a central mediator. The role of IL-13 is strictly related, via complex
signaling pathways, to eosinophil recruitment and activation, to mucus secretion, periostin
generation and to fibrogenic processes (which are part of the remodeling process). These …
diseases, allowed to identify cells, biological functions, cytokines, and receptors that are
preferentially involved in each disease. This is the case of asthma, where IL-13 (together
with IL-4) is recognized as a central mediator. The role of IL-13 is strictly related, via complex
signaling pathways, to eosinophil recruitment and activation, to mucus secretion, periostin
generation and to fibrogenic processes (which are part of the remodeling process). These …