[HTML][HTML] Stringent control of NFE2L3 (nuclear factor, erythroid 2-like 3; NRF3) protein degradation by FBW7 (F-box/WD repeat-containing protein 7) and glycogen …

MB Kannan, I Dodard-Friedman, V Blank - Journal of Biological Chemistry, 2015 - ASBMB
The NFE2L3 transcription factor has been implicated in various cellular processes, including
carcinogenesis, stress response, differentiation, and inflammation. Previously it has been
shown that NFE2L3 has a rapid turnover and is stabilized by proteasomal inhibitors. The
mechanisms regulating the degradation of this protein have not been investigated. Here we
report ubiquitination of NFE2L3 and demonstrate that F-box/WD repeat-containing protein 7
(FBW7 or FBWX7), a component of Skp1, Cullin 1, F-box containing complex (SCF)-type E3 …