Tracking adipogenesis during white adipose tissue development, expansion and regeneration

QA Wang, C Tao, RK Gupta, PE Scherer - Nature medicine, 2013 - nature.com
Nature medicine, 2013nature.com
White adipose tissue displays high plasticity. We developed a system for the inducible,
permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We
monitored adipogenesis during development, high-fat diet (HFD) feeding and cold
exposure. During cold-induced'browning'of subcutaneous fat, most'beige'adipocytes stem
from de novo–differentiated adipocytes. During HFD feeding, epididymal fat initiates
adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period …
Abstract
White adipose tissue displays high plasticity. We developed a system for the inducible, permanent labeling of mature adipocytes that we called the AdipoChaser mouse. We monitored adipogenesis during development, high-fat diet (HFD) feeding and cold exposure. During cold-induced 'browning' of subcutaneous fat, most 'beige' adipocytes stem from de novo–differentiated adipocytes. During HFD feeding, epididymal fat initiates adipogenesis after 4 weeks, whereas subcutaneous fat undergoes hypertrophy for a period of up to 12 weeks. Gonadal fat develops postnatally, whereas subcutaneous fat develops between embryonic days 14 and 18. Our results highlight the extensive differences in adipogenic potential in various fat depots.
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