Contributions of B cells to lupus pathogenesis
A Sang, YY Zheng, L Morel - Molecular immunology, 2014 - Elsevier
A Sang, YY Zheng, L Morel
Molecular immunology, 2014•ElsevierSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
production of autoantibodies. This review summarizes first the results obtained in the mouse
that have revealed how B cell tolerance is breached in SLE. We then review the B cell
subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis,
focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the
interactions between B cells and other immune cells that have been implicated in SLE, such …
production of autoantibodies. This review summarizes first the results obtained in the mouse
that have revealed how B cell tolerance is breached in SLE. We then review the B cell
subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis,
focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the
interactions between B cells and other immune cells that have been implicated in SLE, such …
Abstract
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of autoantibodies. This review summarizes first the results obtained in the mouse that have revealed how B cell tolerance is breached in SLE. We then review the B cell subsets, in addition to the autoAb producing cells, which contribute to SLE pathogenesis, focusing on marginal zone B cells, B-1 cells and regulatory B cells. Finally, we review the interactions between B cells and other immune cells that have been implicated in SLE, such as dendritic cells, macrophages, neutrophils and T cells.
Elsevier