[HTML][HTML] Upregulation of Hsp90-beta and annexin A1 correlates with poor survival and lymphatic metastasis in lung cancer patients
R Biaoxue, J Xiling, Y Shuanying, Z Wei… - Journal of Experimental …, 2012 - Springer
R Biaoxue, J Xiling, Y Shuanying, Z Wei, C Xiguang, W Jinsui, Z Min
Journal of Experimental & Clinical Cancer Research, 2012•SpringerBackground Hsp90-beta and annexin A1 were investigated as prognostic factors because of
their apparent association with tumorigenesis. However, the effect of Hsp90-beta and
annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and
annexin A1 in lung cancer and normal lung specimens were examined, and the
relationships with respect to the clinico-pathological features and patient survival in lung
cancer were analyzed. Methods The expression levels of Hsp90-beta and annexin A1 were …
their apparent association with tumorigenesis. However, the effect of Hsp90-beta and
annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and
annexin A1 in lung cancer and normal lung specimens were examined, and the
relationships with respect to the clinico-pathological features and patient survival in lung
cancer were analyzed. Methods The expression levels of Hsp90-beta and annexin A1 were …
Background
Hsp90-beta and annexin A1 were investigated as prognostic factors because of their apparent association with tumorigenesis. However, the effect of Hsp90-beta and annexin A1 in lung cancer remains poorly understood. The expressions of Hsp90-beta and annexin A1 in lung cancer and normal lung specimens were examined, and the relationships with respect to the clinico-pathological features and patient survival in lung cancer were analyzed.
Methods
The expression levels of Hsp90-beta and annexin A1 were examined using immunohistochemistry, in-situ hybridization, and Western blot.
Results
Lung cancer tissues exhibited higher expression levels of Hsp90-beta and annexin A1 than the normal tissues (p < 0.05), and the expression levels of the markers were significantly associated with the pathological grade and lymphatic invasion of lung cancer (p < 0.05). Moreover, the upregulation of Hsp90-beta and annexin A1 correlated with decreased survival (p < 0.05).
Conclusion
The upregulation of Hsp90-beta and annexin A1 were associated with poor post-surgical survival time and lymphatic metastasis of lung cancer patients. Moreover, the high expression of the markers was an independent predictor of poor outcomes.
Springer