The mitochondrial biogenesis regulatory program in cardiac adaptation to ischemia—a putative target for therapeutic intervention
CJ McLeod, I Pagel, MN Sack - Trends in cardiovascular medicine, 2005 - Elsevier
The resurgence of mitochondrial biology research stems from the realization that the distinct
regulation of mitochondria to meet diverse homeostatic demands is driven by exquisite
biochemical and molecular control mechanisms. This program termed mitochondrial
biogenesis is integral to orchestrating mitochondrial function and appears to exhibit adaptive
remodeling following biomechanical and oxidative stress. The major bioenergetic function of
mitochondria partitions the final utilization of oxygen between oxidative phosphorylation and …
regulation of mitochondria to meet diverse homeostatic demands is driven by exquisite
biochemical and molecular control mechanisms. This program termed mitochondrial
biogenesis is integral to orchestrating mitochondrial function and appears to exhibit adaptive
remodeling following biomechanical and oxidative stress. The major bioenergetic function of
mitochondria partitions the final utilization of oxygen between oxidative phosphorylation and …