The SLC2 (GLUT) family of membrane transporters

M Mueckler, B Thorens - Molecular aspects of medicine, 2013 - Elsevier
GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator
superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human
and they are categorized into three classes based on sequence similarity. All GLUTs appear
to transport hexoses or polyols when expressed ectopically, but the primary physiological
substrates for several of the GLUTs remain uncertain. GLUTs 1–5 are the most thoroughly
studied and all have well established roles as glucose and/or fructose transporters in …