Quantitative evaluation of simian immunodeficiency virus infection using NASBA technology
JW Romano, RN Shurtliff, E Dobratz, A Gibson… - Journal of virological …, 2000 - Elsevier
The most commonly used animal model for the study of HIV-1 infection in humans is the
infection of non-human primates by simian immunodeficiency virus (SIV). The animal hosts
used most frequently are different species of macaques, which are readily infected with SIV,
and can therefore be used to study natural infection, pathogenesis, therapy, and vaccine
efficacy. The study of HIV-1 infection in humans relies heavily on the quantification of HIV-1
load (ie viral RNA) in patient plasma. Given the importance of HIV-1 RNA levels in humans …
infection of non-human primates by simian immunodeficiency virus (SIV). The animal hosts
used most frequently are different species of macaques, which are readily infected with SIV,
and can therefore be used to study natural infection, pathogenesis, therapy, and vaccine
efficacy. The study of HIV-1 infection in humans relies heavily on the quantification of HIV-1
load (ie viral RNA) in patient plasma. Given the importance of HIV-1 RNA levels in humans …