CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production

MP Bernard, RP Phipps - Clinical immunology, 2007 - Elsevier
Synthetic CpG oligodeoxynucleotides (ODN), similar to DNA sequences found in certain
microorganisms, have shown promise as adjuvants for humans by enhancing immune
responses. Since antibodies are often indicators of successful vaccination, it is important to
understand how CpG ODNs affect human B cells and influence antibody production.
Treatment of human B cells with synthetic CpG ODN sequences increased both steady-state
Cox-2 mRNA levels and protein expression. B cell receptor stimulation in concert with CpG …