Severe asthma is associated with a loss of LX4, an endogenous anti-inflammatory compound
I Vachier, C Bonnans, C Chavis, M Farce… - Journal of Allergy and …, 2005 - Elsevier
BACKGROUND: Lipoxins and 15-epi-lipoxins are lipid mediators that modulate leukocyte
trafficking and promote the inflammation resolution. They are produced by different
enzymatic pathways. Patients with severe asthma present ongoing airway inflammation
despite chronic long-term treatment including oral glucocorticoids. OBJECTIVES: The aim of
this study was to assess the presence of proinflammatory and anti-inflammatory mediators in
the supernatants of induced sputum. METHODS: Induced sputum supernatants were …
trafficking and promote the inflammation resolution. They are produced by different
enzymatic pathways. Patients with severe asthma present ongoing airway inflammation
despite chronic long-term treatment including oral glucocorticoids. OBJECTIVES: The aim of
this study was to assess the presence of proinflammatory and anti-inflammatory mediators in
the supernatants of induced sputum. METHODS: Induced sputum supernatants were …