Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators

CN Serhan, N Chiang, TE Van Dyke - Nature Reviews Immunology, 2008 - nature.com
CN Serhan, N Chiang, TE Van Dyke
Nature Reviews Immunology, 2008nature.com
Active resolution of acute inflammation is a previously unrecognized interface between
innate and adaptive immunity. Once thought to be a passive process, the resolution of
inflammation is now shown to involve active biochemical programmes that enable inflamed
tissues to return to homeostasis. This Review presents new cellular and molecular
mechanisms for the resolution of inflammation, revealing key roles for eicosanoids, such as
lipoxins, and recently discovered families of endogenous chemical mediators, termed …
Abstract
Active resolution of acute inflammation is a previously unrecognized interface between innate and adaptive immunity. Once thought to be a passive process, the resolution of inflammation is now shown to involve active biochemical programmes that enable inflamed tissues to return to homeostasis. This Review presents new cellular and molecular mechanisms for the resolution of inflammation, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and protectins. These mediators have anti-inflammatory and pro-resolution properties, thereby protecting organs from collateral damage, stimulating the clearance of inflammatory debris and promoting mucosal antimicrobial defence.
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